教育与工作经历

2023.02至今               亚洲bet57365游戏大厅，副教授

2020.11-2022.11           波士顿学院 (Boston College), 美国，博士后，导师: Jianmin Gao教授

2018.11-2020.11           伊利诺伊大学芝加哥分校 (University of Illinois at Chicago), 美国，博士后，导师: Daesung Lee教授

2016.10-2018.11           中国科学院福建物质结构研究所，博士后，苏伟平 教授

2011.9-2016.9               浙江大学化学系，博士，导师：史炳锋 教授，吴军教授

2007.9-2011.6               学院学院，本科，导师：陈义平 教授，史炳锋 教授

教学简介

担任本科生必修课程《有机化学A》助教

科研简介

主要从事有机化学与多肽化学生物学交叉领域研究，致力于利用有机化学工具解决生物分子（特别是天然多肽）的结构修饰与功能调控难题，为新型多肽药物的开发提供新途径。已在Nat. Rev. Chem.、Angew. Chem. Int. Ed. 、Chem. Sci.、Org. Lett.、Org. Chem. Front.等国际刊物上发表SCI论文19篇，其中2篇论文入选ESI高被引论文，1篇热点论文，1篇VIP论文，论文总被引用1100余次。研究成果先后多次被 ChemInform, Synfacts, Chin. J. Org. Chem.等作为亮点进行报道。主持并参与多项国家自然科学基金项目。

科研领域主要涉及：

1． 复杂环肽的合成

2． 天然多肽的特异性修饰与转化

3． 惰性化学键的活化与转化

社会兼职

代表性论文

19. Chen, Fa-Jie* "Another Side of Side Chains" Nat. Rev. Chem. 2024. https://doi.org/10.1038/s41570-024-00609-y.

18. Gu, Wang; Huang, Jingrong, Lu, Yichi; Lin, Wanzhen*; Xu Wei*; Chen, Fa-Jie* "Synthesis of Glycoconjugates through Chlorooxime-Thiol Conjugation" J. Org. Chem., 2024, 89, 9, 6364–6370.

17. Chen, Fa-Jie*;# Lin, Wanzhen;# Chen, Fen-Er* "Non-symmetric Stapling of Native Peptides" Nat. Rev. Chem., 2024, https://doi.org/10.1038/s41570-024-00591-5.

16. Chen, Fa-Jie*;# Pinnette, Nicole;# Gao, Jianmin*. "Strategies for the Construction of Multicyclic Phage Display Libraries" ChemBioChem, 2024, e202400072.

15. Ying, Junjie; Huang, Jingrong; Liu, Chenguang; Chen, Fa-Jie*; Xu, Chunfa*; Chen, Fen-Er* "Cu-Catalyzed Arylation of S-Tosyl Peptides with Arylboronic Acids" Org. Chem. Front., 2024, 11, 53-59.

14. Chen, Fa-Jie;# Pinnette, Nicole;# Yang, Fan; Gao, Jianmin* "A Cysteine-Directed Proximity-Driven Crosslinking Method for Native Peptide Bicyclization" Angew. Chem. Int. Ed. 2023, e202306813.

13. Chen, Fa-Jie; Gao, Jianmin.* "Fast Cysteine Bioconjugation Chemistry" Chem. Eur. J. 2022, e202201843. (Invited Review)

12. Chen, Fa-Jie;^# Zheng, Mengmeng,^# Nobile, Vincent, Gao, Jianmin.* "Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes" Chem. Eur. J. 2022, e202200058. (Hot paper)

11. Chen, Fa-Jie; Mamidipalli, Phani; Sabbasani, Venkatareddy; Liu, Huaqing; Lee, Daesung* Xia, Yuanzhi*. "Three-component Coupling Reaction for the Synthesis of Fully Substituted Triazoles: Reactivity Control of Cu-Acetylide toward Alkyl Azides and Diazo Compounds" Org. Chem. Front., 2021, 8, 6095.

10. Chen, Fa-Jie; Hua, Zhenguo; Chen, Jianhui; Chen, Jiajia; Lee, Daesung* and Xia, Yuanzhi*. "One-Pot Synthesis of (Z)-β-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation" Front. Chem. 2020, 8, 621545.

9. Chen, Fa-Jie; Lin, Yongjia; Xu, Man; Xia, Yuanzhi*; Wink, Donald J.; Lee, Daesung*. "C–H Insertion by Alkylidene Carbenes to Form 1,2,3-Triazines and Anionic [3 + 2] Dipolar Cycloadditions To Form Tetrazoles: Crucial Roles of Stereoelectronic and Steric Effects" Org. Lett. 2020, 22, 2, 718-723.

8. Chen, Fa-Jie; Liao, Gang; Li, Xin; Wu, Jun*; Shi, Bing-Feng* "Copper-Mediated C–S/N–S Bond Formation via C–H Activation: Access to Benzoisothiazolones Using Elemental Sulfur" Org. Lett. 2014, 6, 5644-5647.

7. Chen, Fa-Jie; Zhao, Sheng; Hu, Fang; Chen, Kai; Zhang, Qi; Zhang, Shuo-Qing; Shi, Bing-Feng.* "Pd(II)-Catalyzed Alkoxylation of Unactivated C(sp³)–H and C(sp²)–H Bonds Using a Removable Directing Group: Efficient Synthesis of Alkyl Ethers" Chem. Sci. 2013, 4, 4187-4192. (Top 25 most-read Chemical Science articles in 2013) (高被引论文)

6. Zheng, Mengmeng; Chen, Fa-Jie, Li, Kaicheng; Reja, Rahi M.; Haeffner, Fredrik; Gao, Jianmin* "Lysine-Targeted Reversible Covalent Ligand Discovery for Proteins via Phage Display" J. Am. Chem. Soc. 2022, 144, 15885-15893.

5. Hu, Rong; Chen, Fa-Jie; Zhang, Xiaofeng; Zhang, Min; Su, Weiping.* "Copper-catalyzed Dehydrogenative γ-C(sp³)-H Amination of Saturated Ketones for Synthesis of Polysubstituted Anilines" Nat. Comm. 2019, 10, 3681.

4. Zhao, Sheng; Chen, Fa-Jie; Liu, Bin; Shi, Bing-Feng.* "Copper-Catalyzed Direct Acyloxylation of C(sp²)-H Bonds with Benzoic Acids" SCIENCE CHINA Chemistry, 2015, 58, 1302-1309.

3. Zhao, Sheng; Liu, Yue-Jin; Yan, Sheng-Yi; Chen, Fa-Jie; Zhang, Zhuo-Zhuo; Shi, Bing-Feng.* "Copper-/Silver-Mediated Arylation of C(sp²)–H Bonds with 2-Thiophenecarboxylic Acids." Org. Lett. 2015, 17, 3338-3341.

2. Li, Xin; Liu, Yan-Hua; Gu, Wen-Jia; Li, Bo; Chen, Fa-Jie; Shi, Bing-Feng.* "Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary" Org. Lett. 2014, 16, 3904-3907.

1. Zhang, Qi; Chen, Kai; Rao, Wei-Hao.; Zhang, Yuejun; Chen, Fa-Jie, Shi, Bing-Feng.* "Stereoselective Synthesis of Chiral α-Amino-β-Lactams via Pd(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp³)–H Bonds" Angew. Chem. Int. Ed. 2013, 52, 13588-13592. (高被引论文）

科研项目

5. 氯肟在多肽衍生物合成中的应用研究(2024T014)，学院贵重仪器设备开放测试基金，2023-2024，在研，主持

4. 天然多肽的特异性修饰与拓扑结构调控研究（511264），学院“旗山学者”海外项目，2023-2027，在研，主持

3. 过渡金属催化的饱和羰基化合物的脱氢/双官能团化串联反应研究（21702205），国家自然科学基金青年项目， 2018-2020，已结题，主持

2. β-取代色氨酸合成方法及其在Maremycins和TMC-95A的合成应用研究（21402170），国家自然科学基金青年项目， 2015-2017，已结题，参与

1. 新型糖肽类抗生素Mannopeptimycins的仿生合成及多样化合成（21272206），国家自然科学基金面上项目，2013-2016，已结题，参与

获奖情况

2023年入选学院“旗山学者”（海外项目）

2018年入选中国科学院福建物质结构研究所“精英博士后”

2015年入选浙江大学“优秀研究生”

2011年获得学院“优秀本科毕业论文”

其他

欢迎对本研究方向感兴趣的同学加入实验室学习交流！